Myeloid Knockout of HIF-1 α Does Not Markedly Affect Hemorrhage/Resuscitation-Induced Inflammation and Hepatic Injury

Figure 5

Hepatic hypoxia was assessed by immunohistological staining of Hypoxyprobe-1 as the marker of tissue ischaemia (red (a)–(d)). Sham-operated animals underwent the same surgical procedures but hemorrhagic shock and resuscitation (H/R) was not carried out. Representative liver sections from wild-type (WT) mice ((a) after sham operation and (c) 6 h after resuscitation, resp.) and HIF-1α knockout (KO) mice ((b) after sham operation and (d) 6 h after H/R) are shown. Bar is 100 μm. Semiquantitative evaluation of hypoxic tissue revealed the extent of hypoxia (e) (^∗𝑃<0.05 versus both sham groups).

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