The Regulatory Role of Activating Transcription Factor 2 in Inflammation

Table 2

Natural products which inhibit ATF-2 signaling pathway.

Compound	Action target on ATF-2	Reference
Andrographolide	Suppressed NO and PGE2 production and ameliorated the symptoms of LPS-induced hepatitis and EtOH/HCl-induced gastritis in mice	[35]
SB203580	Inhibition of the inflammatory cytokines IL-1𝛽 and TNF-𝛼	[36]
JIP-1	Enhances phagocytic activity, downregulation of TNF-𝛼, IL-1𝛽, IL-6, IFN-𝛾, IL-12, and IL-18	[36]
LY294002	Inhibition of proinflammatory cytokines NO and TNF-𝛼	[36]
Biochanin-A	Inhibition of IL-6, IL-1𝛽, and TNF-𝛼 production in RAW264.7 cells	[37]
Pimaric acid	Suppression of MMP-9 induction and migration of human aortic smooth muscle cells	[38]
Nomilin	Inhibition of proinflammatory cytokine production	[39]
Berberine	Attenuation of COX-2 overexpression during acute endotoxemia	[40]
Genistein	Inhibition of infection of cells with the New World arenavirus Pichindé (PICV)	[41]
Piperine	Reduction of proinflammatory cytokines: IL-1𝛽, IL-6, TNF-𝛼, GM-CSF, and MMPs	[42]