Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits

Figure 3

Analysis of lipoprotein profiles. Lipoprotein profiles were analyzed by agarose gel electrophoresis (top) and HPLC (bottom left). Post-Triton VLDL production rate in fasting rabbits was measured. Blood was drawn at 0 minutes (before administration of Triton WR-1339) and 2, 4, and 6 hours after Triton WR-1339 injection. VLDL-TG (𝑑<1.006g/mL) contents were quantified (bottom right). ASO-treated rabbits showed increased levels of β-migrating particles (both VLDL and chylomicron remnants) at the origin. VLDL synthesis rate (expressed by the slope of each line) was the same in ASO-treated rabbits as in the control. Data are expressed as the mean ± SD ∗ or ^∗∗𝑃<0.05 or 0.01 versus control. 𝑛=4-5 for each group.