Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia

Figure 1

The representative images of TTC staining and MRI outcome show the effects of DAHP and TP on MCAO-induced focal cerebral ischemia in rats. (a) Mean change in infarction volume is significant in MCAO group (MCAO), DAHP treatment group (DAHP), and TP treatment group (TP) in comparison with the normal control (control). Infarction area was less in the treatment groups than the MCAO group, thus presenting their neuroprotective effects. Data is expressed as means ± SEM (–10); , , and compared with normal control. (b) Compared with vehicle group (vehicle) and control, the images show hyperintensity in MCAO, DAHP, and TP, among which MCAO has the largest hyperintensity areas. (c) The images of TTC staining in each group show the same tendency of ischemia infarction as the MRI results; DAHP and TP attenuate cerebral ischemia. TTC staining results revealed that the differences in infarction areas were significant in rats pretreated by DAHP and TP, which is consistent with MRI results.