Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients

Figure 2

Panobinostat treatment was associated with reductions in the proportions of CD69⁺ intestinal T cells. (a–h) Flow cytometric analyses were performed on freshly isolated LPMCs. Intestinal CD4⁺ T cells (a-b; e-f) and CD8⁺ T cells (c-d; g-h) were assessed for CD69 (a–d) or HLA-DR (e–h) expression. The proportion of cells expressing the respective activation marker is graphed in the left column while the levels of marker expression are represented in the right column. Each patient participant is represented in all figures by the same distinct symbol. Wilcoxon matched-pairs signed rank tests were used to generate the reported values.

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