Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor T-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis

Table 2

Comparison of miRNA expression profiles between sarcoidosis (S) patients, subdivided according to the outcome after 2-year follow-up (Reg: regression; Prog: progression), and control subjects (C). All the data are presented as Mean Expression Level (95% confidence interval). Results are expressed relative to levels of endogenous U6 miRNA. : number of patients. Bold font indicates significant value.

	S	Reg S	Prog S	C
	( = 48)	( = 28)	( = 20)	( = 14)	(Kruskal-Wallis)	S versus C	Reg versus Prog
miR-let-7c-5p	0.058; (0.051–0.066)	0.051; (0.042–0.060)	0.069; (0.056–0.082)	0.069; (0.052–0.087)	0.127	0.239	0.039
miR-let-7d-5p	0.136; (0.118–0.154)	0.124; (0.100–0.147)	0.153; (0.126–0.181)	0.155; (0.120–0.190)	0.250	0.256	0.103
miR-21-5p	2.022; (1.618–2.427)	1.676; (1.300–2.051)	2.508; (1.693–3.323)	2.023; (1.253–2.794)	0.585	0.833	0.161
miR-24-3p	0.522; (0.462–0.582)	0.488; (0.409–0.567)	0.570; (0.473–0.667)	0.571; (0.432–0.711)	0.432	0.405	0.174
miR-25-3p	0.110; (0.071–0.150)	0.117; (0.050–0.184)	0.101; (0.077–0.124)	0.089; (0.042–0.137)	0.485	0.434	0.191
miR-92a-3p	0.364; (0.312–0.416)	0.319; (0.255–0.384)	0.421; (0.336–0.506)	0.362; (0.272–0.452)	0.277	0.814	0.061
miR-125a-5p	0.044; (0.034–0.054)	0.046; (0.029–0.062)	0.042; (0.031–0.052)	0.058; (0.020–0.096)	0.982	0.814	0.770
miR-126-3p	0.054; (0.005–0.102)	0.077; (0.007–0.160)	0.021; (0.012–0.030)	0.057; (0.004–0.118)	0.992	0.860	0.810
miR-133a-3p	0.012; (0.010–0.015)	0.012; (0.008–0.015)	0.013; (0.009–0.017)	0.014; (0.010–0.018)	0.589	0.248	0.557
miR-146a-5p	0.304; (0.266–0.342)	0.294; (0.235–0.352)	0.319; (0.271–0.366)	0.196; (0.135–0.257)	0.020	0.006	0.331
miR-148a-3p	0.061; (0.050–0.072)	0.056; (0.042–0.069)	0.068; (0.049–0.087)	0.074; (0.050–0.097)	0.507	0.342	0.268
miR-150-5p	0.280; (0.219–0.340)	0.277; (0.199–0.355)	0.283; (0.179–0.386)	0.093; (0.061–0.125)	<0.001	<0.001	0.983
miR-155-5p	0.200; (0.170–0.231)	0.169; (0.138–0.200)	0.244; (0.187–0.300)	0.168; (0.126–0.210)	0.111	0.550	0.017
miR-181a-5p	0.106; (0.091–0.121)	0.102; (0.084–0.120)	0.112; (0.085–0.139)	0.122; (0.091–0.153)	0.650	0.263	0.630
miR-199a-5p	0.012; (0.010–0.014)	0.011; (0.008–0.014)	0.013; (0.009–0.016)	0.016; (0.007–0.024)	0.919	0.748	0.532
miR-202-3p	0.009; (0.008–0.011)	0.010; (0.007–0.013)	0.013; (0.006–0.020)	0.014; (0.009–0.019)	0.173	0.036	0.564
miR-204-5p	0.008; (0.006–0.010)	0.006; (0.005–0.007)	0.010; (0.005–0.015)	0.011; (0.007–0.015)	0.030	0.031	0.061
miR-206	0.026; (0.002–0.064)	0.039; (0.003–0.101)	0.010; (0.001–0.021)	0.005; (0.003–0.007)	0.999	0.928	0.963
miR-212-3p	0.010; (0.008–0.013)	0.010; (0.008–0.012)	0.011; (0.006–0.017)	0.012; (0.009–0.016)	0.490	0.158	0.705
miR-214-3p	0.009; (0.006–0.011)	0.008; (0.006–0.010)	0.010; (0.005–0.014)	0.010; (0.005–0.014)	0.968	0.866	0.621
miR-222-3p	0.038; (0.029–0.048)	0.059; (0.047–0.072)	0.065; (0.050–0.080)	0.062; (0.052–0.071)	0.059	0.012	0.668
miR-223-3p	0.808; (0.679–0.936)	0.815; (0.615–1.014)	0.798; (0.644–0.951)	0.901; (0.695–1.106)	0.692	0.270	0.826
miR-302c-3p	0.061; (0.048–0.074)	0.060; (0.041–0.079)	0.065; (0.046–0.083)	0.089; (0.034–0.143)	0.820	0.427	0.631
miR-424-5p	0.103; (0.002–0.289)	0.013; (0.002–0.025)	0.009; (0.006–0.012)	0.018; (0.005–0.031)	0.426	0.143	0.905
miR-503-5p	0.038; (0.030–0.046)	0.041; (0.030–0.052)	0.035; (0.023–0.046)	0.058; (0.022–0.094)	0.480	0.643	0.112