Mediators of Inflammation / 2015 / Article / Tab 3 / Research Article
Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor T-bet , and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis Table 3 Comparison of mRNA expression profiles of studied cytokines, chemokines, chemokine receptors, and
T-bet between sarcoidosis (S) patients, subdivided according to the outcome after 2-year follow-up (Reg: regression; Prog: progression), and control subjects (C). All the data are presented as Mean Expression Level (95% confidence interval). Results are expressed relative to levels of a housekeeping gene PSMB2.
: number of patients. Bold font indicates significant
value.
S Reg S Prog S C ( = 48) ( = 28) ( = 20) ( = 14) (Kruskal-Wallis) C versus S Reg versus Prog CCL2 0.058 (0.051–0.066) 0.051 (0.042–0.060) 0.069 (0.056–0.082) 0.069 (0.052–0.087) 0.950 0.602 0.875 CCL3 0.136 (0.118–0.154) 0.124 (0.100–0.147) 0.153 (0.126–0.181) 0.155 (0.120–0.190) 0.110 0.043 0.237 CCL4 2.022 (1.618–2.427) 1.676 (1.300–2.051) 2.508 (1.693–3.323) 2.023 (1.253–2.794) 0.157 0.034 0.746 CCL5 0.522 (0.462–0.582) 0.488 (0.409–0.567) 0.570 (0.473–0.667) 0.571 (0.432–0.711) 0.002 <0.001 0.834 CCL7 0.110 (0.071–0.150) 0.117 (0.050–0.184) 0.101 (0.077–0.124) 0.089 (0.042–0.137) 0.500 0.152 1.000 CCL8 0.364 (0.312–0.416) 0.319 (0.255–0.384) 0.421 (0.336–0.506) 0.362 (0.272–0.452) 0.147 0.031 1.000 CCL13 0.044 (0.034–0.054) 0.046 (0.029–0.062) 0.042 (0.031–0.052) 0.058 (0.020–0.096) 0.861 0.939 0.420 CCL19 0.054 (0.005–0.102) 0.077 (0.007–0.160) 0.021 (0.012–0.030) 0.057 (0.004–0.118) 0.477 0.216 0.403 CXCL2 0.012 (0.010–0.015) 0.012 (0.008–0.015) 0.013 (0.009–0.017) 0.014 (0.010–0.018) 0.429 0.414 0.161 CXCL3 0.304 (0.266–0.342) 0.294 (0.235–0.352) 0.319 (0.271–0.366) 0.196 (0.135–0.257) 0.069 0.608 0.011 CXCL9 0.061 (0.050–0.072) 0.056 (0.042–0.069) 0.068 (0.049–0.087) 0.074 (0.050–0.097) 0.005 <0.001 0.670 CXCL10 0.280 (0.219–0.340) 0.277 (0.199–0.355) 0.283 (0.179–0.386) 0.093 (0.061–0.125) 0.009 0.002 0.925 CXCL11 0.200 (0.170–0.231) 0.169 (0.138–0.200) 0.244 (0.187–0.300) 0.168 (0.126–0.210) 0.045 0.008 0.754 CXCL12 0.106 (0.091–0.121) 0.102 (0.084–0.120) 0.112 (0.085–0.139) 0.122 (0.091–0.153) 0.180 0.101 0.204 CXCL16 0.012 (0.010–0.014) 0.011 (0.008–0.014) 0.013 (0.009–0.016) 0.016 (0.007–0.024) 0.241 0.982 0.612 CCR1 0.009 (0.008–0.011) 0.010 (0.007–0.013) 0.013 (0.006–0.020) 0.014 (0.009–0.019) 0.289 0.277 0.112 CCR2-var.A 0.008 (0.006–0.010) 0.006 (0.005–0.007) 0.010 (0.005–0.015) 0.011 (0.007–0.015) 0.051 0.018 0.241 CCR2-var.B 0.026 (0.002–0.064) 0.039 (0.003–0.101) 0.010 (0.001–0.021) 0.005 (0.003–0.007) 0.779 0.444 0.587 CCR5 0.010 (0.008–0.013) 0.010 (0.008–0.012) 0.011 (0.006–0.017) 0.012 (0.009–0.016) 0.016 0.003 0.427 CXCR3 0.009 (0.006–0.011) 0.008 (0.006–0.010) 0.010 (0.005–0.014) 0.010 (0.005–0.014) 0.002 <0.001 0.691 CXCR4 0.038 (0.029–0.048) 0.059 (0.047–0.072) 0.065 (0.050–0.080) 0.062 (0.052–0.071) 0.295 0.152 0.271 CXCR6 0.808 (0.679–0.936) 0.815 (0.615–1.014) 0.798 (0.644–0.951) 0.901 (0.695–1.106) <0.001 <0.001 0.616 CXCR7 0.061 (0.048–0.074) 0.060 (0.041–0.079) 0.065 (0.046–0.083) 0.089 (0.034–0.143) 0.667 0.392 0.417 IL2 0.103 (0.002–0.289) 0.013 (0.002–0.025) 0.009 (0.006–0.012) 0.018 (0.005–0.031) <0.001 <0.001 0.730 IL2RA 0.038 (0.030–0.046) 0.041 (0.030–0.052) 0.035 (0.023–0.046) 0.058 (0.022–0.094) 0.210 0.051 0.730 IL2RB 0.038 (0.029–0.048) 0.059 (0.047–0.072) 0.065 (0.050–0.080) 0.062 (0.052–0.071) 0.131 0.049 0.272 IL15RA 0.808 (0.679–0.936) 0.815 (0.615–1.014) 0.798 (0.644–0.951) 0.901 (0.695–1.106) 0.182 0.048 0.530 IFNG 0.061 (0.048–0.074) 0.060 (0.041–0.079) 0.065 (0.046–0.083) 0.089 (0.034–0.143) <0.001 <0.001 0.565 T-bet 0.103 (0.002–0.289) 0.013 (0.002–0.025) 0.009 (0.006–0.012) 0.018 (0.005–0.031) 0.031 0.006 0.573