Review Article

Transforming Growth Factor Beta Family: Insight into the Role of Growth Factors in Regulation of Fracture Healing Biology and Potential Clinical Applications

Figure 1

A schematic representation of TGF-β superfamily. TGF-β: transforming growth factor beta; GDF: growth and differentiation factor; ACT: activin; INH: inhibin; other ligands include Müllerian inhibiting substance (MIS) or anti-Müllerian hormone (AMH), left-right determination factor (Lefty), and nodal growth differentiation factor (Nodal); GDNF: glial-derived neurotrophic factors; BMPs: bone morphogenetic proteins.