iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants

Figure 1

Impaired angiogenesis in implants from iNOS^−/− mice. Hemoglobin content (a). Blood vessels density (b). VEGF levels (c). Representative photomicrographs of H&E-stained histological sections (d). The sponges were collected for analyses at day 14 after implantation. Values were represented as means (± SEM) from groups of 8 animals each. , versus WT group (Student’s -test). Bar 50 μm. Asterisks indicate the synthetic matrix. White arrows indicate blood vessels.

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