3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway

Figure 3

Protecting effects of AC-Rsv on the LPS exposure induced lung injuries. (a–d) Morphological changes were evaluated 12 h after LPS exposure by H&E staining. LPS stimulation group (b) showed increasing lung edema, alveolar hemorrhage, neutrophil infiltration, and destroyed epithelial/endothelial cell structures compared with those of control (a), while significant improvement was observed in samples from the LPS + AC-Rsv group (c). AC-Rsv treatment alone barely affected the structure of lungs (d). (e) Wet-to-dry ratios of lung samples; data are expressed as mean ± S.D. . LPS injection significantly increased the W/D ratios of lung samples compared with that of control, versus control, while pretreatment of AC-Rsv dramatically decreased the W/D ratios of lung samples stimulated by LPS, versus . ((f) and (g)) Protein concentration (a) and cell count (b) in BALF. Data are expressed as mean ± S.D. . LPS exposure significantly increased cell and protein content in BALF compared with those of control, versus control; and pretreatment of AC-Rsv decreased the cell and protein content in BALF from lung stimulated by LPS, versus .

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