Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α⁻¹⁹³ (G/A)

Table 3

Genotype frequencies of TNF-⁻²³⁸ (G/A) among cases and controls and the association with gastric pathology.

	Genotypes	Genotyping frequency	MAF	HWE	value
Controls	G/G	58 (78.4)	0.11	1.05^E
	G/A	15 (20.3)
	A/A	1 (1.3)
Gastritis	G/G	55 (98.2)	0.01	0.016^E	0.001^S
	A/G	1 (1.8)
	A/A	0
Ulcer	G/G	20 (95.2)	0.02	0.19^E	0.07^NS
	A/G	1 (4.8)
	A/A	0
Adenocarcinoma	G/G	88 (94.6)	0.03	0.12^E	0.002^S
	A/G	5 (5.4)
	A/A	0

Data are expressed as %. TNF-: tumor necrosis factor alpha; A/G: adenine/guanidine; MAF: minor allele frequency; HWE: Hardy-Weinberg equilibrium; E: population in equilibrium for TNF-⁻²³⁸ polymorphism; S: significant; NS: not significant ORs with 95% CI; and values were calculated for wild/wild genotype versus wild/mutant and mutant/mutant genotypes.