Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction

Figure 1

TSA facilitated the recovery from LPS-induced anorexia and increased line crossing (locomotor activity). Mice were pretreated with saline (Controls) or TSA (0.3 mg/kg) for 1 h and then intraperitoneally challenged with saline or E. coli LPS (1 mg/kg). (a) Body weight, (b) food intake, and (c) water intake were measured before an LPS injection and then again 24 h later. (d) Line crossing was measured before the LPS injection and then again 2, 4, 8, and 24 h later. Bars and graphs present means ± SEM (). compared with the Control group; ^# compared with the LPS-only group.

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