Anti-Inflammatory Effects of a Methanol Extract from the Marine Sponge Geodia cydonium on the Human Breast Cancer MCF-7 Cell Line

Figure 4

Interactomic analysis by ingenuity pathway analysis (IPA) of significant molecules. The interactome shows the close functional association between significant cytokines (indicated with green symbols) as well as the paths in which other functionally relevant molecules are also involved (indicated with white symbols). In detail, the cytokines reported are CXCL8 (C-X-C motif ligand 8), CCL2 (C-C motif ligand 2), VEGF (vascular endothelial growth factor), IFNG (interferon gamma), CXCL10 (C-X-C motif ligand 10), and TNF (tumor necrosis factor alpha). Moreover, three HUB nodes such as ESR1 (estrogen receptor 1), NF-κB (nuclear factor kappa B), and RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A) subunits are indicated by cyan symbols.