Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One-Lung Ventilation in Patients

Table 2

Perioperative time-course changes of blood gas variables in DISO group ( = 25) and NISO group () ().

Parameters	Group	TLV-15 min	OLV-10 min	OLV-20 min	OLV-30 min	OLV-40 min
pH	DISO	7.37 ± 0.04	7.38 ± 0.03	7.39 ± 0.04	7.40 ± 0.03	7.39 ± 0.04
	NISO	7.37 ± 0.04	7.38 ± 0.03	7.39 ± 0.04	7.40 ± 0.03	7.39 ± 0.04
Hb (mg/L)	DISO	118.5 ± 10.7	116.9 ± 12.5	117.5 ± 11.6	116.1 ± 14.2	115.3 ± 12.5
	NISO	117.4 ± 12.4	117.0 ± 12.3	116.9 ± 14.3	115.9 ± 12.7	115.1 ± 13.4
Qs/Qt (%)	DISO	11.5 ± 1.8	23.5 ± 2.9^ab	25.3 ± 2.3^ab	27.1 ± 2.1^ab	23.5 ± 2.2^ab
	NISO	12.0 ± 1.1	28.1 ± 2.5^a	30.1 ± 2.0^a	31.9 ± 1.9^a	27.7 ± 2.0^a
PaCO2 (mmHg)	DISO	34.8 ± 3.2	35.0 ± 3.1	35.1 ± 3.9	35.3 ± 4.1	35.1 ± 3.3
	NISO	35.2 ± 3.1	35.7 ± 4.5	36.0 ± 3.7	35.7 ± 4.0	35.5 ± 4.2
SaO2 (%)	DISO	99.7 ± 0.1	99.0 ± 1.2	98.7 ± 0.3	98.4 ± 0.8	99.3 ± 0.5
	NISO	99.7 ± 0.4	98.9 ± 0.7	98.4 ± 1.1	97.5 ± 1.5	99.2 ± 0.6
ScvO2 (%)	DISO	84.9 ± 9.1	84.5 ± 8.5	83.5 ± 6.9	82.2 ± 9.2	84.4 ± 5.9
	NISO	84.5 ± 8.5	83.6 ± 7.1	81.7 ± 7.3	80.7 ± 9.4	82.7 ± 5.5
HR (beats/min)	DISO	66.3 ± 9.2^b	65.5 ± 13.1^b	67.5 ± 12.1^b	68.7 ± 11.2^b	67.6 ± 11.3^b
	NISO	77.5 ± 10.5	78.2 ± 12.8	78.7 ± 13.3	81.5 ± 14.1	78.4 ± 14.3
MAP (mmHg)	DISO	78.9 ± 17.2	77.2 ± 12.5	76.1 ± 10.5	75.0 ± 16.2	76.6 ± 13.4
	NISO	81.1 ± 15.7	79.1 ± 14.2	79.1 ± 14.7	77.5 ± 17.1	77.9 ± 15.3
PaO2 (mmHg)	DISO	457.5 ± 85.2	258.6 ± 68.6^ab	198.5 ± 68.3^ab	185.6 ± 73.2^ab	209.6 ± 85.1^ab
	NISO	461.5 ± 87.5	223.5 ± 89.7^a	165.2 ± 75.3^a	151.3 ± 68.5^a	171.6 ± 88.9^a

< 0.05 versus TLV-15 min; < 0.05 versus NISO group.