CD4+RORγt++ and Tregs in a Mouse Model of Diet-Induced Nonalcoholic Steatohepatitis

Figure 3

Immune cells, cytokines, and adipokines modifications after high fat diet (HFD). Th17 were significantly increased in liver and abdominal adipose tissue (AAT) of mice fed a HFD while Tregs were significantly increased in the subcutaneous adipose tissue (SAT). After HFD there was an increase in the leptin gene expression in the adipose tissue, more pronounced in the SAT. Moreover there was a positive cytokine response to HFD in liver and adipose tissue (both AAT and SAT).