<i>γ</i>-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation

<div>GSI decreased Notch1 and NICD. BALB/C mice were sensitized i.p. with OVA and challenged with OVA in the presence and absence of GSI. (a) The expression of Notch1 mRNA was evaluated by quantitative real-time RT-PCR. GAPDH was used as internal control. (b) Protein levels of NICD were examined by Western blotting. <i>β</i>-actin was used as a loading control. (A) Sham group; (B) OVA + DMSO; (C) OVA + GSI. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: <i>γ</i>-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation 

Mediators of Inflammation

γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation

Figure 3