Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation

Figure 3

Intrathecal administration of BD1047 delayed bone cancer induced mechanical allodynia. Sigma-1 receptor antagonist BD1047 or normal saline (NS) was intrathecally injected on days 5, 6, and 7 after inoculation (). The PWT of BCP rats was increased after injection of BD1047 on day 7. Results are given as means ± SEM. , versus sham + NS group; , versus BCP + NS group.