Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus

Figure 4

Maresin 1 abolishes capsaicin- (CAP-) induced enhancement in synaptic transmission and TMJ inflammation-induced synaptic plasticity in the trigeminal nucleus. (a) Spontaneous excitatory postsynaptic currents (sEPSCs) traces in Sp5C lamina II neurons of trigeminal nuclei slices before and after capsaicin (500 nM) and maresin 1 perfusion (0.35 nM). (b) Maresin 1 (0.35 nM) blocked capsaicin-induced sEPSC frequency increase (, versus pretreatment baseline, , -test). ((c) (A and B)) Traces of sEPSCs in a trigeminal nuclei slice from control and complete Freund’s adjuvant- (CFA-) inflamed (1 day) mice showing sEPSC increases after TMJ inflammation and its inhibition by maresin 1 (0.35 nM). (d) sEPSC frequency and amplitude in the control and CFA-inflamed conditions and the actions of maresin 1 (, compared to noninflamed control; , compared to CFA-inflamed control, , two-way ANOVA).

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