Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases

Figure 1

The interaction between Myc and mediators of inflammation. Arrow = positive regulation, Dot arrow = positive regulation with unclear mechanisms. Arrows in beginning and end = regulation of each other positively. Bar = negative regulation. IL-2RA: interleukin 2 (IL-2) receptor alpha. (A) Interaction of Myc, IL-1, and IL-1β. (B) Interaction between IL-2, IL-2RA, Jun, and Myc. (C) Interaction between IL-4, NF-κB, p53, and c-Myc. (D) Interaction between IL-6, NF-κB, AP-1, and c-Myc. (E) Interaction between IL-8, NF-κB, and c-Myc. (F) Interaction between IL-10, NF-κB, AP-1, and c-Myc. (G) Interaction between TNF-α, NF-κB, AP-1 and c-Myc. (H) Interaction between TGF-β, NF-κB, and c-Myc.