Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases

Table 2

Genes	Functions	Expression in chronic liver diseases	References
IL-1	It activates T and B cells and monocytes	Up	[123, 132, 135, 138]
IL-2	It is necessary for the growth, proliferation, and differentiation of thymic-derived lymphocytes (T cells)	Up, down	[133]
IL-4	It induces secretion of Ig by B cells, pleiotropic effect on T cells	Up	[123]
IL-6	It is an important mediator of fever and of the acute phase response and stimulates thymocyte proliferation and fibroblast growth factor activity	Up	[137, 139]
IL-8	It acts as neutrophil chemotactic factor and can induce chemotaxis in target cells, primarily neutrophils, and also other granulocytes, causing them to migrate toward the site of infection	Up	[120, 128, 134]
IL-10	It stimulates proliferation of B cells, thymocytes, and mast cells, stimulates IgA production by B cells, and also enhances B cell survival	Up, down	[123, 124, 138]
Jun	It is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies	Up	[124]
NF-B	Upon activation of either T or B cell receptor, it upregulates genes involved in T cell development, maturation, and proliferation	Up	[130]
TGF-	It suppresses T cell growth and differentiation	Up, down	[121, 139]
TNF-	It is an adipokine involved in systemic inflammation, is a member of a group of cytokines that stimulate the acute phase reaction, and is a mediator of immune functions in the regulation of immune cells	Up, down	[140]