Fas/FasL Pathway Participates in Regulation of Antiviral and Inflammatory Response during Mousepox Infection of Lungs

Figure 1

Lack of Fas and FasL expression results in an increased infection burden during mousepox infection. (a) Fas and FasL expression in the lungs of C57BL/6 mice uninfected and ECTV-infected at the 7th d.p.i. Brown color indicates a positive reaction (Fas+ or FasL−), while blue color corresponds with hematoxylin positive nuclei. (b, c) C57BL/6 (WT), B6. MRL-Faslpr/J (Fas−), and B6Smn.C3-Faslgld/J (FasL−) mice ( in each group) were infected with 1 × 10³ PFU of ECTV-MOS and monitored for 14 days. Kaplan-Meier survival analysis using the log-rank test (b) and (c) ECTV titers in lungs. Asterisks along the lines indicate statistical differences between the mice strains. The bars represent the mean from 5 separate experiments ± SEM. Significant differences with in comparison to Fas- and FasL-deficient mice.

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