Fas/FasL Pathway Participates in Regulation of Antiviral and Inflammatory Response during Mousepox Infection of Lungs

Figure 2

Lack of Fas or FasL leads to disturbances in the inflammatory response. (a) Histological analysis of lungs isolated from ECTV-infected Fas (−), FasL (−), and WT (C57BL/6) mice at 7 and 10 days of infection and uninfected controls. The nuclei were counterstained with Harris haematoxylin (violet) (×40 and 100). Total counts of alveolar macrophages (b) and inflammatory monocytes (b) in cell suspensions prepared from the lungs isolated from Fas (−), FasL (−), and WT (C57BL/6) mice at 3, 7, 10, and 14 days of ECTV infection and from control, uninfected mice. The bars represent the mean from 5 separate experiments ± SEM. Significant differences with and in comparison to wild-type mice.

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