Fas/FasL Pathway Participates in Regulation of Antiviral and Inflammatory Response during Mousepox Infection of Lungs

Figure 4

Lack of Fas or FasL during mousepox infection results in disturbances of cytokine and chemokine production. Relative mRNA levels of CXCL1, CXCL9, IL-10, IL-15, and TGF-β1 in the lungs isolated from Fas (−), FasL (−), and WT (C57BL/6) mice at 3, 7, 10, and 14 days of ECTV infection and from control, uninfected mice. The mRNA expressions were normalized by that of GAPDH, and the lungs of control, uninfected mice were estimated as 1. The bars represent the mean from 3 separate experiments ± SEM. Significant differences with and .

(a)

(b)

(c)

(d)

(e)