Fas/FasL Pathway Participates in Regulation of Antiviral and Inflammatory Response during Mousepox Infection of Lungs

Table 1

Production of TNF-alpha, CXCL1, and CXCL9 in pg/mL in the supernatant of epithelial Hepa 1–6 cells and bone marrow derived macrophages (BMMF) cocultures infected or not with ECTV for 24 h and incubated or not in the presence of 10 g/mL of anti-FasL-blocking antibody (clone MFL-4). All results represent means from 3 separate experiments ± SEM.

	(−)	FasL-blocking Ab
TNF-alpha
Control	49.5 ± 5.3	46.8 ± 5.2
ECTV	25.5 ± 3.1^*	33.3 ± 4.02^*
CXCL1
Control	40.8 ± 5.1	36.7 ± 2.9
ECTV	24.5 ± 2^*	16.8 ± 0.9^*†
CXCL9
Control	45.5 ± 3.1	42 ± 4.5
ECTV	29.1 ± 1.7^*	14.5 ± 1.3^*†

Significant differences with , by -test in comparison to control, uninfected cultures. Significant difference () by -test in comparison to cultures nontreated with FasL-blocking antibody.