Fas/FasL Pathway Participates in Regulation of Antiviral and Inflammatory Response during Mousepox Infection of Lungs
Table 2
Percentages of cells expressing IL-10, IL-15, CXCL1, and CXCL9 in the lungs isolated from ECTV-infected Fas (−), FasL (−), and WT (C57BL/6) mice at 3rd, 7th, 10th, and 14th days of infection and uninfected controls. All results represent means from 3 separate experiments ± SEM.
Control
Day 3
Day 7
Day 10
Day 14
% IL-10 expressing cells
WT
10.23 ± 2.11
12.28 ± 2.88
11.22 ± 1.01
7.56 ± 0.34
0.0
Fas (−)
11.07 ± 2.34
5.2 ± 0.42**
4.82 ± 0.22*
8.7 ± 0.99
11.8 ± 1.78**
FasL (−)
8.99 ± 2.67
6.11 ± 0.41**
5.33 ± 0.69*
9.8 ± 1.2
13.1 ± 1.2**
% IL-15 expressing cells
WT
0.89 ± 0.13
5.56 ± 0.44
7.23 ± 0.47
7.1 ± 0.67
1.9 ± 0.55
Fas (−)
0.94 ± 0.15
1.89 ± 0.2*
2.1 ± 0.09**
1.23 ± 0.01*
0.89 ± 0.31
FasL (−)
0.97 ± 0.11
1.99 ± 0.19*
1.7 ± 0.18**
1.41 ± 0.12*
0.79 ± 0.47
% CXCL1 expressing cells
WT
5.23 ± 0.66
11.45 ± 2.34
28.23 ± 1.07
8.89 ± 0.76
6.54 ± 0.59
Fas (−)
4.59 ± 0.45
23.9 ± 3.1*
8.7 ± 1.3**
7.65 ± 0.8
5.49 ± 0.87
FasL (−)
6.01 ± 0.55
28.23 ± 2.66**
9.1 ± 1.08**
7.05 ± 0.69
6.3 ± 0.65
% CXCL9 expressing cells
WT
2.7 ± 0.22
3.5 ± 0.3
16.8 ± 1.22
5.3 ± 0.43
3.7 ± 0.33
Fas (−)
2.45 ± 0.2
2.7 ± 0.44
2.51 ± 0.3 **
17.69 ± 2.1*
8.45 ± 0.9*
FasL (−)
1.99 ± 0.34
3.5 ± 0.32
3.09 ± 0.23**
19.99 ± 2*
7.96 ± 0.88*
Significant differences with ≤ 0.05 and ** ≤ 0.01 by -test in comparison to control, uninfected cultures.
