PK2/PKR1 Signaling Regulates Bladder Function and Sensation in Rats with Cyclophosphamide-Induced Cystitis

Figure 2

PKR1 immunohistochemical staining in the bladder sections ((a) control; (b) 4 h; (c) 48 h; (d) 8 d). PKR1 protein expression was primarily detected in the urothelium and markedly increased in all rats that suffered from CYP-induced cystitis regardless of duration. (e) A section serves as the negative control incubated with the primary PKR1 antibody absorbed onto the blocking peptide. Sample size = 5–7 for each group. Magnification: (a, b, c, d) 10x; (e) 4x.

(a)

(b)

(c)

(d)

(e)