Clinical Study
Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile
Table 2
Genotype frequencies of the polymorphisms located in the genes studied in Crohn’s disease patients: both responders and nonresponders to infliximab.
| | Responders | Nonresponders | | | % | | % |
| Gene S100A9 | | | | | rs11205276 | | | | | GG | 189 | 67 | 39 | 67 | GC | 88 | 31 | 18 | 31 | CC | 4 | 2 | 1 | 2 | rs3014866 | | | | | CC | 94 | 33 | 22 | 37 | CT | 129 | 46 | 30 | 51 | TT | 58 | 21 | 7 | 12 | Gene S100A12 | | | | | rs724781 | | | | | CC | 128 | 46 | 27 | 47 | CG | 115 | 41 | 27 | 47 | GG | 37 | 13 | 4 | 6 | Gene S100A8 | | | | | rs3006488 | | | | | AA | 235 | 83 | 47 | 78 | AG | 44 | 15 | 12 | 20 | GG | 5 | 2 | 1 | 2 | Gene G0S2 | | | | | rs4844486 | | | | | CC | 145 | 52 | 33 | 54 | CA | 115 | 42 | 26 | 43 | AA | 18 | 6 | 2 | 3 | rs1473683 | | | | | GG | 269 | 97 | 54 | 95 | GT | 7 | 3 | 3 | 5 | TT | 0 | 0 | 0 | 0 | GENE TNFAIP6 | | | | | rs11677200* | | | | | TT | 79 | 29 | 26 | 45 | TC | 153 | 56 | 24 | 41 | CC | 42 | 15 | 8 | 14 | rs2342910 | | | | | AA | 138 | 52 | 30 | 57 | AT | 113 | 42 | 18 | 34 | TT | 16 | 6 | 5 | 9 | rs3755480 | | | | | GG | 218 | 78 | 44 | 72 | GA | 57 | 20 | 15 | 25 | AA | 6 | 2 | 2 | 3 | rs10432475 | | | | | AA | 224 | 80 | 44 | 77 | AG | 54 | 19 | 12 | 21 | GG | 2 | 1 | 1 | 2 | Gene IL11 | | | | | rs1126760 | | | | | TT | 165 | 60 | 28 | 52 | TC | 94 | 34 | 24 | 44 | CC | 16 | 6 | 2 | 4 | rs1042506 | | | | | TT | 195 | 76 | 37 | 77 | TG | 52 | 20 | 11 | 23 | GG | 9 | 4 | 0 | 0 |
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CC genotype, P = 0.017; OR (95% CI) = 0.5 (0.27–0.93).
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