Glycyrrhizic Acid Promotes M1 Macrophage Polarization in Murine Bone Marrow-Derived Macrophages Associated with the Activation of JNK and NF-κB

Figure 8

Effect of ERK1/2 pathway on GA-induced IL-10 production in M1-polarized BMDMs. BMDMs were pretreated with ERK1/2 inhibitor (U0126, 10 μM) followed by treatment with GA (100 μg/mL) for (a) 6 h or (b) 48 h, and IL-10 mRNA expression and IL-10 secretion were measured by real-time PCR and ELISA, respectively. Data are mean ± SD for three independent experiments. , (-test).

(a)

(b)