Cellular and Molecular Connections between Autophagy and Inflammation

Figure 1

Autophagy and inflammation. By integrating output signals from PRRs (brown box), cytokines, and chemokines (blue box) and ROS (orange box), autophagy regulatory network is able to dynamically respond to inflammation. Transcriptionally, inflammation-related transcription factors shape transcriptional program of autophagy (grey box). Active autophagy reduces inflammation at least by mediating damaged organelles clearance, lowering microorganisms intracellular load and degrading inflammatory mediators (red box).