PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy

Table 2

Univariate and multivariate analyses for recurrence-free survival (Cox proportional hazard model).

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Age (≥65 versus <65 year old)	1.116	0.652–1.908	0.689
Sex (male versus female)	0.844	0.495–1.441	0.535
Tumor site
Colon versus rectum	1.075	0.635–1.821	0.788
Histology
Poor versus well/moderate	1.548	0.832–2.881	0.168
Lymph node metastasis
≥ 4 versus < 4	2.160	1.230–3.793	0.007	0.832	0.409–1.693	0.612
TNM stage
IIIC versus IIIA + IIIB	4.001	2.281–7.017	<0.001	5.057	2.478–10.323	<0.001
PPP1R12A (low versus high)	2.186	1.293–3.696	0.003	2.596	1.500–4.490	0.001

Bold items highlight , HR: hazard ratio, CI: confidence interval; TNM: tumor node metastasis.