PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy

Table 3

Univariate and multivariate analyses for overall survival (Cox proportional hazard model).

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Age (≥65 versus <65 year old)	1.301	0.716–2.363	0.387
Sex (male versus female)	0.754	0.414–1.372	0.355
Tumor site
Colon versus rectum	1.202	0.661–2.187	0.546
Histology
Poor versus well/moderate	2.310	1.208–4.418	0.011	2.242	1.128–4.455	0.021
Lymph node metastasis
≥ 4 versus < 4	2.750	1.497–5.050	0.001	1.050	0.492–2.243	0.899
TNM stage
IIIC versus IIIA + IIIB	3.613	1.919–6.803	<0.001	3.913	1.831–8.366	<0.001
PPP1R12A (low versus high)	2.782	1.531–5.052	<0.001	2.976	1.602–5.528	0.001

Bold items highlight ; HR: hazard ratio; CI: confidence interval; TNM: tumor node metastasis.