Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut

Figure 1

Predicted structural domains within mouse Gimap5. (a) Mouse Gimap5 is a 308-amino acid protein that contains an AIG1 domain (residues 24–227), a P-loop NTPase domain (residues 1–168), two coiled-coil domains (residues 187–221 and 239–265), and a transmembrane domain (residues 284–304). The GC missense mutation in sphinx mice at residue 38 is indicated. (b) Schematic overview of the domain features present in the different Gimap family members.

(a)

(b)