Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b⁺Gr-1⁺ Myeloid-Derived Suppressor Cells Require HMGB1

Figure 1

Time course of the changes in accumulation of CD11b⁺Gr-1⁺ myeloid-derived suppressor cells (MDSCs) after pseudofracture (PF) in mice. (a) Representative flow cytometric analysis and (b) graphic analysis of the percentages of CD11b⁺Gr-1⁺ cells in bone marrow cells, blood leukocytes, and splenocytes in mice at time points after injury. ; versus control time point. Data represent means ± SEM; mice per time point.

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