Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b⁺Gr-1⁺ Myeloid-Derived Suppressor Cells Require HMGB1

Figure 3

Anti-HMGB1 neutralizing mAb ameliorates attenuated T-cell responses at late time points, but not the early inflammatory responses or hepatic injury after pseudofracture (PF). Plasma IL-6 (a), ALT (b), and AST (c) at 6 h and 48 h after PF in control and HMGB1 Ab-treated mice. Splenocytes were isolated for T-cell proliferation in response to con A (d) and Th1/2 cytokines production ((e), (f)) at 48 h after PF. ; versus corresponding uninjured control group. Data represent means ± SEM; = 6–8 mice per group.

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