Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-<i>κ</i>B Pathway in Rheumatoid Arthritis Synovial Cells

<div>Alternations of multiple intracellular pathways by 4-HNE treatment in MH7A synovial cells. Histograms showing that multiple intracellular pathways are altered by 4-HNE treatment (5 <i>μ</i>M for 3 h) through Millipore Luminex assays. Noted that insulin receptor (IR), AKT, mTOR, and GSK pathways are downregulated by 4-HNE treatment (blow) and NF-<i>κ</i>B, MAPK, and STATs pathways are upregulated (red, NF-<i>κ</i>B green).</div>

Mediators of Inflammation

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Figure 1

Figure 1: Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-<i>κ</i>B Pathway in Rheumatoid Arthritis Synovial Cells 

Figure 1 | Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells 