Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells

Figure 3

Induced COX-2 expression by 4-HNE treatment in MH7A synovial cells. ((a)-(b)) Western blots and histograms showing that the protein levels of COX-2 are induced by 4-HNE treatment of low concentration (5 μM) for 0~12 h. ((c)-(d)) Western blots and histograms showing that the protein levels of COX-2 are increased by 4-HNE treatment of high concentration (50 μM) for 0~3 h and dramatically decreased in the following 3~12 h. Results are the averages of three independent experiments. Data represent mean ± SEM. ^∗, ^∗∗, and ^∗∗∗.

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