Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells

Figure 7

Inhibition of NF-κB may partly rescue cell death by 4-HNE in MH7A synovial cells. Histograms showing that percentage of cell apoptosis are partly reduced by BAY11-7082 treatment (10 μM) under the condition of 4-HNE treatment of low concentration (5 μM, 0~12 h) (a) and high concentration (50 μM, 0~3 h) (b). Results are averages of five independent experiments. Data represent mean ± SEM. ^∗, ^∗∗, and ^∗∗∗.

(a)

(b)