Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

Figure 2

(a) Flow cytometry analysis of surface CD73 expression on cells of popliteal and inguinal lymph nodes from naïve, control, and EAMG animals. Gating strategies are indicated on dot plots on the left. Dot plots on the right show CD73 expression within cells and are a representative example of each indicated group. Numbers inside dot plots correspond to mean percentage SEM of cells. (b) Percentage of cells (left) and mean fluorescence intensity (MFI) due to CD73 (right) staining within the indicated cell populations. Bars represent means SEM of 5 experiments for each animal group. , (one-way ANOVA and Bonferroni’s post hoc test) compared to naïve and control animals, respectively.

(a)

(b)