Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo

<div>Chemical structure and specificity of the synthesized MMP inhibitor. (a) The target compound consists of a Zn2+-binding group (ZBG) and a terphenyl which resides in the deep S1′ pocket of the MMP catalytic domain [<a href="/journals/mi/2015/510679/#B21">21</a>]. (b) List of in vitro determined IC50 values (μM) which indicates that the inhibitor is very specific towards MMP-12 with an IC50 in the nanomolar range. (c) Fitted dose-response curve relation to MMP-12 used to calculate the IC50.</div>

Mediators of Inflammation

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Figure 1: Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo

Figure 1 | Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo 