Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

Figure 5

Histopathological assessment of acetaminophen-induced liver injury (APAP). (a) Liver histology (H&E) showing that while control mice have a healthy liver architecture and absence of necrosis, APAP-treated mice had several necrotic areas with leukocyte infiltration (green arrow). (b) Digital quantification of necrotic areas using ImageJ, histopathological score, and neutrophil infiltration (assessed by MPO levels) confirmed severe liver inflammation and necrosis induced by cocaine. Statistical significance in comparison to controls (). One-way ANOVA with Tukey’s post hoc test. Data are expressed as ( mice/treatment).

(a)

(b)