Excessive Daytime Sleepiness Is Associated with Changes in Salivary Inflammatory Genes Transcripts

Table 2

Salivary transcript levels in patients with sleep apnea compared to controls.

Gene	Abbreviation	Sleep apnea fold from control^a	value
-actin	ACTB	1.43 ± 0.38	0.191
Arachidonate 5-lipoxygenase	ALOX5	1.39 ± 0.36	0.238
Arachidonate 12-lipoxygenase	ALOX12	1.56 ± 0.69	0.404
Annexin A1	ANXA1	4.62 ± 1.15	0.003^b
Annexin A3	ANXA3	1.26 ± 0.38	0.444
Annexin A5	ANXA5	2.05 ± 0.92	0.168
-2-microglobulin	B2M	2.65 ± 0.70	0.007^b
Caspase 1, apoptosis-related cysteine peptidase	CASP1	2.57 ± 0.81	0.025
Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	2.66 ± 0.81	0.019
Intercellular adhesion molecule 1	ICAM1	0.44 ± 0.13	0.123
Interleukin 1 receptor, type II	IL1R2	1.62 ± 0.41	0.143
Interleukin 2 receptor, gamma	IL2RG	2.36 ± 0.72	0.054
Integrin, alpha M	ITGAM	1.50 ± 0.61	0.376
Integrin, beta 2	ITGB2	1.47 ± 0.31	0.167
Mitogen-activated protein kinase 1	MAPK1	1.72 ± 0.66	0.401
Mitogen-activated protein kinase 3	MAPK3	1.30 ± 0.41	0.585
Mitogen-activated protein kinase 14	MAPK14	1.85 ± 0.53	0.089
Phosphodiesterase 4B, cAMP-specific	PDE4B	1.49 ± 0.21	0.168
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	PTGS2	3.73 ± 0.98	0.002^b
Tumor necrosis factor receptor superfamily, member 1A	TNFRSF1A	1.32 ± 0.20	0.206
Tumor necrosis factor receptor superfamily, member 1B	TNFRSF1B	1.07 ± 0.44	0.900

Mean ± SEM.
^bSignificant difference using 5% FDR post hoc test.