Excessive Daytime Sleepiness Is Associated with Changes in Salivary Inflammatory Genes Transcripts

Table 4

Salivary transcript levels in “sleepy” patients compared to controls.

Gene	Abbreviation	Sleepy people fold from control^a	value
-actin	ACTB	1.86 ± 0.47	0.033
Arachidonate 5-lipoxygenase	ALOX5	1.30 ± 0.46	0.472
Arachidonate 12-lipoxygenase	ALOX12	0.53 ± 0.33	0.408
Annexin A1	ANXA1	2.86 ± 1.37	0.099
Annexin A3	ANXA3	2.64 ± 0.85	0.010
Annexin A5	ANXA5	2.29 ± 0.76	0.054
-2-microglobulin	B2M	3.33 ± 1.34	0.013
Caspase 1, apoptosis-related cysteine peptidase	CASP1	5.36 ± 2.07	0.001^b
Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	2.35 ± 0.88	0.068
Intercellular adhesion molecule 1	ICAM1	0.61 ± 0.33	0.441
Interleukin 1 receptor, type II	IL1R2	2.04 ± 0.75	0.092
Interleukin 2 receptor, gamma	IL2RG	3.53 ± 2.25	0.118
Integrin, alpha M	ITGAM	1.64 ± 0.65	0.292
Integrin, beta 2	ITGB2	1.84 ± 0.52	0.102
Mitogen-activated protein kinase 1	MAPK1	1.55 ± 0.65	0.510
Mitogen-activated protein kinase 3	MAPK3	1.06 ± 0.42	0.921
Mitogen-activated protein kinase 14	MAPK14	2.33 ± 0.77	0.057
Phosphodiesterase 4B, cAMP-specific	PDE4B	1.69 ± 0.69	0.259
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	PTGS2	3.80 ± 1.34	0.005^b
Tumor necrosis factor receptor superfamily, member 1A	TNFRSF1A	1.87 ± 0.62	0.096
Tumor necrosis factor receptor superfamily, member 1B	TNFRSF1B	1.80 ± 0.88	0.322

Mean ± SEM.
^bSignificant difference using 5% FDR post hoc test.