Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

Table 1

SP600125 effects on lung histologic damage in CLP mice. is for .

	Parameters	Sham	CLP	CLP + SP600125
Lung	Inflammatory infiltrate	0	2.31 ± 0.41	1.28 ± 0.23^***
	Vascular congestion	0	2 ± 0.18	1.1 ± 0.37^***
	Interstitial edema	0	2.12 ± 0.53	1.32 ± 0.44^***
Liver	Inflammatory infiltrate	0	2.1 ± 0.39	1.3 ± 0.33^***
	Steatosis	0	2.89 ± 0.56	1.56 ± 0.26^***
	Necrosis	0	2.2 ± 0.47	0.9 ± 0.21^***
	Ballooning degeneration	0	2.76 ± 0.47	1.58 ± 0.48^***