Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles

Figure 3

The histological appearance of colonic mucosa of intact rat (a) and the colonic mucosa of rat with TNBS colitis fed normal diet (b) or fed HFD without exercise (c) and HFD with exercise (d) at day 14 after TNBS induction. Note the normal architecture of the colonic crypts in intact rat (a) and the severe damage as manifested by a partial loss of normal architecture and deep ulceration reaching muscularis mucosa (b). This histological damage was potentiated in untrained rat fed HFD showing complete loss of architecture accompanied by severe inflammation (c). In contrast, in trained rat fed HFD, both the area of colonic damage and the inflammatory reaction were reduced and more regeneration around the ulceration was evidently seen (d).

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