Toll-Like Receptor-4 Mediated Inflammation Is Involved in the Cardiometabolic Alterations Induced by Intermittent Hypoxia

Figure 1

TLR4 signaling is involved in IH-induced epididymal fat alterations. Morphological and inflammatory changes of epididymal fat pads were studied in C57BL/6 and TLR4^−/− mice exposed to intermittent hypoxia (IH) or normoxia (N) for 4 weeks. (a) Measurements of weight of bilateral epididymal fat pads ( = 13–15 per group), (b) mice body weights ( = 13–15 per group), (c) adipocyte size ( = 4–6 per group), and (d) representative photographs of adipose tissue remodeling. Inflammation was studied through the release of TNF-α (e) and IL-6 (f) ( = 6–8 per group). IH/C57BL/6 versus N/C57BL/6.

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