Toll-Like Receptor-4 Mediated Inflammation Is Involved in the Cardiometabolic Alterations Induced by Intermittent Hypoxia

Figure 2

TLR4 signaling is involved in IH-induced insulin resistance. Glucose variation during the 90 minutes of the intraperitoneal insulin tolerance test (IpITT) in C57BL/6 or TLR4^−/− mice exposed to 1 week of intermittent hypoxia (IH) or normoxia (N) (a). IpITT presented separately for C57BL/6 (b) and TLR4^−/− mice (c). For each group, lowest blood glucose level (nadir) during the 90 minutes of the IpITT (d). IH/C57BL/6 versus N/C57BL/6, = 13–15 per group.

(a)

(b)

(c)

(d)