Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents

Figure 3

Serum irisin levels. (a) Serum irisin levels in rats fed with high fat (HF) and low fat (LF) diet for 10 weeks (b) Serum irisin levels in leptin deficient mice (ob/ob) versus wild type (WT) mice fed ad libitum. (c) Serum irisin levels in animals fed ad libitum (FED), fasted for 48 hours (FAST 48 h) or refed for 24 hours (REFED 24 h) after 48 hours of fasting. (d) Serum irisin levels in ob/ob mice fed ad libitum, 36 hours fasted, and in ob/ob mice fed ad libitum after leptin treatment. Values are mean ± SEM of the mean of 6–12 animals per group. A was considered significant.

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