Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI

Figure 1

Identification of KC and determination of the purity of KC cultures. KC were identified by IF staining for CD68 (a) and the phagocytosis of fluorescent latex beads (b). The percentages of CD68-positive and phagocytosis-positive cells isolated with an adherence separation step (w ASS) or without an adherence separation step (w/o ASS) are shown in (c). Data are shown as box plots, representing the median, the interquartile range, and minimum and maximum values. At least (unpaired -test), , .

(a)

(b)

(c)