Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI

Figure 3

APAP-, DIC- or LPS-induced stimulation of KC. APAP (a), DIC (b), or LPS (c) in different concentrations were used for the stimulation of KC for 24 h. The intracellular ROI formation was investigated by the DCF assay. The detected ROI levels were normalized to the cell viability measured by means of the XTT assay. Data show means ± SEM. , , , and .

(a)

(b)

(c)