Research Article

Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI

Table 1

Anamnesis data of investigated donors.

DiagnosisSexAgeBMINotes

HealthyAdenomaF4829
Cholangiocellular carcinomaF5020

MultimorbidityKlatskin tumorM8031Hypercholesterolemia
Colorectal liver metastasisM7223Coronary heart disease
Cholangiocellular carcinomaM7429Diabetes, hypertension, and in situ split
Gall bladder carcinomaF5728Portal vein embolisation, hypertension, and cholestasis
Cholangiocellular carcinomaF7524Hypercholesterolemia
Cholangiocellular carcinomaM6131Hypertension, hypercholesterolemia
HemangiomaF4328.4Diabetes
Cholangiocellular carcinomaM4723Terminal renal failure, hypercholesterolemia

Chronic inflammationKlatskin tumorM7224Chronic inflammation, diabetes, and hypertension

Portal vein embolisationColorectal liver metastasisF60Portal vein embolisation
Colorectal liver metastasisM5728Portal vein embolisation, chemotherapy

CholestasisCholangiocellular carcinomaF7222Cholestasis
Cholangiocellular carcinomaF7722Cholestasis

ChemotherapyColorectal liver metastasisF71Chemotherapy

Hepatic steatosisHepatocellular carcinomaM75Resection area, steatohepatitis
AdenomaF32Diabetes, steatohepatitis

Resection areaHemangiomaM4727Resection area
Cholangiocellular carcinomaM6225Resection area, chemotherapy

Donor AFocal nodular hyperplasiaF1922

Donor BColorectal liver metastasisM5023Diabetes, smoker

Donor CKlatskin tumorM5225Diabetes, portal vein embolisation